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doi:10.1093/carcin/23.10.1721

Reactive metabolites from lipid peroxidation disrupt essential cellular structures, initiating cell death and DAMP releasea process further amplified by antioxidant depletion and exemplified in SLE, where neutrophils undergo ferroptosis and NETosis, activating TLR-dependent ROS generation that propagates inflammatory tissue injury (76, 87, 113115)